Bradford was 5 of 8 for 68 yards to cap a 14-play, 84-yard drive. St. Louis (6-6-1) continued its late-season resurgence by winning its third straight for the first time since closing the 2006 season with three victories.
The Bills (5-8) all but mathematically dropped out of playoff contention by blowing a lead in the final minute of the fourth quarter for the second time this season.